Applegate established a successful film and television career in her adult years, winning a Primetime Emmy Award from seven nominations as well as nominations for four Golden Globe Awards and a Tony Award.

Applegate starred in the title role of the NBC sitcom Jesse (1998–2000), which earned her a Golden Globe Award nomination.

She received a Primetime Emmy Award for her guest role in the NBC sitcom Friends (2002–2003).

For her role in the Broadway revival of Sweet Charity (2005), she earned a nomination for the Tony Award for Best Actress in a Musical.

Applegate was born in Hollywood, Los Angeles, California.

Her father, Robert William "Bob" Applegate, was a record producer and record company executive;her mother, Nancy Priddy, is a singer and actress.

Her parents separated shortly after her birth. She has two half-siblings, Alisa and Kyle, from her father's second marriage.

After her divorce, Applegate's mother had a relationship with musician Stephen Stills.

Her father, Robert William "Bob" Applegate, was a record producer and record company executive;her mother, Nancy Priddy, is a singer and actress.